Ioannis Mitroulis

This paper develops a mathematical model to study how local and global inflammation affects hematopoiesis and clonal expansion, identifying feedback thresholds that drive disease progression.

This study shows exercise induces anti-inflammatory reprogramming in macrophages via Hsp60, identified through secretome analysis and proteomic profiling.

This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.