Laura C. Murphy

The paper shows that PRC1 and PRC2 are independently recruited to hypomethylated pericentromeric heterochromatin in mESCs without requiring specific mediators.

The paper shows chronic lysosome damage from Palbociclib treatment in cancer cells triggers interferon responses via mitochondrial nucleic acid release, dependent on lysosome-mitochondrion contacts.

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

The paper identifies TUBB4B mutations causing distinct ciliopathic diseases by affecting microtubule dynamics and cilia formation in humans and mice.

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

The paper identifies rare CRE variants associated with X-linked intellectual disability by combining sequencing, functional assays in zebrafish and mice, and phenotypic analysis.

The paper introduces FIVER, a multispectral reporter for in vivo genome editing that detects NHEJ, HDR, and HITI with fluorescent read-outs, demonstrating its utility in primary cells, organoids, and in vivo models.

The paper identifies an ER-localized NMD pathway that regulates the stability of ER-translated mRNAs through the interaction of NBAS and UPF1.

This study shows that a DISC1 mutation linked to mental illness disrupts NMDAR dynamics and synaptic function in neurons, affecting excitatory synapses and vesicle dynamics.