David Bending

This study shows vancomycin impairs macrophage fungal killing by disrupting mitochondrial function and morphology, independent of microbiome effects.

This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.

A conjugate vaccine targeting Robo4 induces anti-Robo4 antibodies, inhibiting tumour growth and vascular development in mouse models.

This study uses a magnetic particle-based platform to mechanically modulate T-cell receptors, showing that NFAT pathway signaling accumulation is required for CD4+ T cell activation.

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.