Author

Alastair Copland

University of BirminghamORCID 0000-0003-3117-3935Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David BendingiD· 3 shared David A.J. LeckyiD· 2 shared Lozan SheriffiD· 2 shared Sophie T. RouvrayiD· 2 shared Amanpreet Singh ChawlaiD· 1 shared Chandrashekhar PasareiD· 1 shared David Cameron WraithiD· 1 shared Elena V. Knatko· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

David BendingORCID

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3 papers

Recent·Most cited

ImmunologyiSciencePeer-reviewedMar 31, 2025

Interferonγ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance

David A.J. Lecky, Lozan Sheriff, Sophie T. Rouvray…·David Bending

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologyImmunotherapy AdvancesPeer-reviewedDec 30, 2024

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

Lozan Sheriff, Alastair Copland, David A.J. Lecky…·David Bending

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 1, 2023

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

Amanpreet Singh Chawla, Harriet J. Watt, Stefan A Schattgen…·Mahima Swamy

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.

1 citation

mouseproteomics

𝕏 PostBluesky