Jianhai Chen

The paper studies tRNA gene evolution in Drosophila, finding rapid duplication and loss, sexual dimorphism in expression, and implications for regulatory diversity.

The paper introduces int2MR, a Mendelian randomization method for detecting exposure-by-group interactions using GWAS summary statistics, showing its effectiveness in identifying sex- and age-group-specific risk factors for ADHD and Alzheimer's disease.

The paper analyzes whole-genome data from wild boars to trace their demographic history and identify genetic signatures of local adaptation in Central Asia.

The paper identifies primate-specific genes as more essential in cancer cell lines and shows their increased co-expression in cancer networks.

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

The paper constructs a fine-scale recombination map in domestic chickens to study rapid evolutionary changes in recombination rates during domestication.

This study examines the rapid structural evolution of de novo genes in rice over 1 million years, finding faster changes in disordered regions and structured elements compared to gene duplicates.

The paper identifies a novel DMD mutation causing cryptorchidism through whole-genome sequencing and CRISPR-Cas9 mouse modeling.

The study uses nanopore sequencing to analyze structural variations in rhesus macaques, finding more SVs on the X chromosome and evidence of positive selection.