Author

William Fisher

University of CambridgeORCID 0000-0003-0163-0111Unclaimed ORCID profile · follow to get notified of new preprints

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Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel N. GrbaiD· 2 shared John J. WrightiD· 2 shared Judy HirstiD· 2 shared Guilherme M. ArantesiD· 1 shared Man Nok Choy· 1 shared Robert A. WaddelliD· 1 shared Zhan YiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

Daniel N. GrbaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 17, 2026

Conformational gating at histidine junctions coordinates proton translocation in respiratory complex I

William W. Fisher, John J. Wright, Man Nok Choy…·Judy Hirst

The paper presents cryo-EM structures of bovine respiratory complex I under varying protonation conditions, revealing conformational changes at histidine junctions that coordinate proton translocation.

DOI 10.64898/2026.08.12.744383

cryo-EMexperimental assay

𝕏 PostBluesky

BiochemistrySciencePeer-reviewedJun 13, 2024

Structural basis of a regulatory switch in mammalian complex I

Daniel N. Grba, John J. Wright, Zhan Yin…·Judy Hirst

This study defines the structural basis of a regulatory switch in mammalian complex I by combining cryoEM structures with biochemical analysis, showing how conformational changes mediate deactivation during ischaemia.

32 citations

𝕏 PostBluesky