Jaimin K. Rana

The paper determines the structure of tau filaments in Alzheimer's disease patients with co-morbid LATE-NC using cryo-electron microscopy, revealing a CTE-type tau fold in addition to the Alzheimer's fold.

This study presents the cryo-EM structure of human TWIK-2 and identifies key residues and modulators, providing a foundation for developing anti-inflammatory therapeutics.

This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.

This study uses in situ cryo-ET to show HPV remains intact during retrograde transport and lysosome residency, challenging existing models of viral disassembly and transport.

The paper reports the crystal structure of the THEMIS CABIT2 domain, revealing a novel fold with an inserted SH3-like domain and insights into its interaction with GRB2.

The paper reports the structure of hSIDT1, revealing its lipid binding domain's conformational flexibility and structural features.

This study determines the high-resolution structure of HGSNAT-acetyl-CoA complex using cryo-EM and maps MPS IIIC mutations to elucidate dysfunction mechanisms.