Shyamal Mosalaganti

This study identifies polyphosphate as a structural component of filopodia that regulates cell adhesion and invasion, with implications for tumor suppression.

The paper determines the structure of tau filaments in Alzheimer's disease patients with co-morbid LATE-NC using cryo-electron microscopy, revealing a CTE-type tau fold in addition to the Alzheimer's fold.

The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.

This study identifies how caveolin-1's hydrophobic residue patterning drives membrane bending through structural and computational analyses.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

This study identifies ZCWPW1 as a chromatin-based regulator of telomere architecture and meiotic chromosome movements, independent of PRDM9.

This study presents the cryo-EM structure of human TWIK-2 and identifies key residues and modulators, providing a foundation for developing anti-inflammatory therapeutics.

This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.

This study shows that paralogs H-NS and StpA form distinct condensates with different phase behaviors, enabling bacteria to adjust condensate stability for stress response.

This study shows that the McdAB system can be used to engineer spatial control of various bacterial organelles in E. coli, enabling programmable positioning for synthetic biology applications.

This study uses in situ cryo-ET to show HPV remains intact during retrograde transport and lysosome residency, challenging existing models of viral disassembly and transport.

This study shows neutrophils release nuclear DNA via exosomes to resolve sterile inflammation, with implications for treating inflammatory diseases.

The paper develops a rapid in situ cryo-ET workflow for bacterial ribosome structure analysis, achieving sub-nm resolution in E. coli within 10 days.

This study shows that endogenous retrovirus-like proteins RTL8 and PEG10 regulate UBQLN2's recruitment to stress granules and alter their functional properties.

This study uses a multimodal cryo-correlative microscopy pipeline to visualize TDP43 mislocalization and aggregation in iPSC-derived neurons and patient tissue, revealing ordered fibrils in autophagosomes and lysosomes.

The paper reports the structure of hSIDT1, revealing its lipid binding domain's conformational flexibility and structural features.

This study determines the high-resolution structure of HGSNAT-acetyl-CoA complex using cryo-EM and maps MPS IIIC mutations to elucidate dysfunction mechanisms.

The paper uses AI to create a dynamic model of the human nuclear pore complex, showing how the protein scaffold interacts with the nuclear envelope.

This study uses cryo electron tomography and simulations to analyze the structure of SARS-CoV-2 spike protein in situ, revealing three hinges in the stalk domain that enable orientational flexibility.

This study benchmarks tomographic acquisition schemes for cryo electron tomography to optimize resolution for subtomogram averaging using HIV-1 lattice.