Michaeljohn Kalakoutis

This study identifies the molecular structural basis of muscle braking, showing it results from both myosin motor conformational changes and filament lattice distortion during stretching.

The paper uses X-ray diffraction to show that fewer myosin motors are attached to actin in slow compared to fast skeletal muscle, revealing distinct structural and signaling mechanisms.

The paper examines how age and physical activity affect muscle fibre size, myonuclear numbers, and myonuclear domain volumes in humans, finding that exercise preserves fibre size and MND relationships while inactivity reduces fibre size and disrupts these relationships.