Tristin A. Schwartze

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

This study investigates how BMP-9 and BMP-10 form disulfide bonds and dimers, showing that geometric strain, not cysteinylation, reduces dimerization propensity and that residue swaps can reverse this effect.

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

The paper investigates how shear stress and low ALK1 ligand levels synergize to activate ALK1 signaling in endothelial cells, revealing kinase activity and endocytosis as critical factors.