Rick M. Maizels

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

This paper improves the folding and targeting of an engineered TGF-β monomer for gene-based delivery by modifying its pro-domain and adding a CD44 binding domain.

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

This study identifies an extracellular Argonaute protein from a parasitic nematode that can be internalized by mouse cells and shows it can be targeted for vaccine development.

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

The paper identifies a helminth miRNA that suppresses host immune responses by targeting key factors involved in cell differentiation and signaling pathways.

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

This study identifies avocado fatty alcohols/acetates (AFAs) as a new class of anthelmintics that target lipid metabolism in parasitic nematodes.

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

This study shows that PD-1 signaling regulates Th2 cell metabolism and IL-33 receptor expression through fatty acid oxidation, suggesting PD-1 blockade could treat Th2-related diseases.