Author

Chenxi Ou

Massachusetts Institute of TechnologyORCID 0000-0003-0312-1943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Gerhard HummeriD· 1 shared James H. HurleyiD· 1 shared James P. RoneyiD· 1 shared Kevin P. LarseniD· 1 shared Phyllis I. HansoniD· 1 shared Sankalp ShuklaiD· 1 shared Sergey OvchinnikoviD· 1 shared Serim YangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Gerhard HummerORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintMar 18, 2026

Protein Diffusion Models as Statistical Potentials

James P. Roney, Chenxi Ou, Sergey Ovchinnikov

This paper introduces ProteinEBM, a protein conformational energy model that outperforms existing methods in predicting mutation effects and protein structures.

4 citations

protein structuredeep learning

𝕏 PostBluesky

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedFeb 22, 2024

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

Sankalp Shukla, Wei Chen, Shanlin Rao…·James H. Hurley

This study investigates how ALG-2 binds membranes and proteins in a Ca2+-dependent manner, revealing its role in membrane repair and ERES function.

23 citations

experimental assaymechanistic / dynamical model

𝕏 PostBluesky