Author

Phyllis I. Hanson

University of MichiganORCID 0000-0001-7983-6668Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Kevin Patrick BohannoniD· 2 shared Wei CheniD· 2 shared Alfredo J. GuerraiD· 1 shared Chenxi OuiD· 1 shared Einar B. Olafsson· 1 shared Gerhard HummeriD· 1 shared Hargobinder KauriD· 1 shared James H. HurleyiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Kevin Patrick BohannonORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 23, 2026

Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity

Hargobinder Kaur, Rebekah B. Guevara, Yolanda Rivera-Cuevas…·Vern B. Carruthers

This paper identifies TgGRA8 as a Toxoplasma protein that recruits ALG-2 to the parasitophorous vacuole, essential for parasite metabolism and ESCRT hijacking.

DOI 10.64898/2026.07.20.739547

metabolomicsexperimental assay

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Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedMay 23, 2024

Ca2+-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress

Wei Chen, Madeline M. Motsinger, Jiaqian Li…·Phyllis I. Hanson

The paper shows that ALG-2, a Ca2+ sensor, recruits ESCRTs to lysosomes to enhance their resilience against osmotic stress-induced rupture.

40 citationstop 1%

experimental assaycell signaling & trafficking

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedFeb 22, 2024

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

Sankalp Shukla, Wei Chen, Shanlin Rao…·James H. Hurley

This study investigates how ALG-2 binds membranes and proteins in a Ca2+-dependent manner, revealing its role in membrane repair and ERES function.

23 citations

experimental assaymechanistic / dynamical model

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