Author

Ryan Lingerak

Case Comprehensive Cancer CenterORCID 0000-0003-0341-1035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Xiaojun ShiiD· 2 shared Aaron P. PettyiD· 1 shared Adam W. SmithiD· 1 shared Arul M. ChinnaiyaniD· 1 shared Bangyan L. StilesiD· 1 shared Bing-Cheng WangiD· 1 shared Bingcheng WangiD· 1 shared Colm M. MorrisseyiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Xiaojun ShiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 25, 2024

Skeletal Metastasis of Prostate Cancer Is Augmented by Activation of EphA2 Noncanonical Signaling and Ligand-Deficient Bone Microenvironment

Ryan Lingerak, Aaron P. Petty, Xiaojun Shi…·Bingcheng Wang

This study shows EphA2 overexpression and loss of its ligands in prostate cancer promote bone metastasis through noncanonical signaling in a ligand-deficient bone microenvironment.

DOI 10.1101/2024.09.25.615079

mousebulk RNA-seq

𝕏 PostBluesky

BiophysicsbioRxivPreprintOct 5, 2023

The SAM Domain of EphA2 Inhibits Ligand-Independent Clustering and Activation

Xiaojun Shi, Ryan Lingerak, Pravesh Shrestha…·Adam W. Smith

This study investigates the role of the SAM domain in EphA2, showing it inhibits ligand-independent clustering and kinase activity in both full-length and intracellular domain constructs.

1 citation

experimental assaycell signaling & trafficking

𝕏 PostBluesky