A. Briegel

The paper identifies a family of over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage function, demonstrating their conservation and novel compound production.

This study shows that ICP1 bacteriophage treatment effectively clears Vibrio cholerae from zebrafish larvae intestines, independent of microbiome composition.

This study shows Chitinophaga pinensis can switch between filamentous and spherical morphologies with distinct transcriptional profiles, impacting its behavior and interactions in the plant microbiome.

The paper develops a multimodal imaging pipeline to enable cryo-ET of symbiotic tissues, revealing nanoscale structural details of host-microbe interactions in Hawaiian bobtail squid.

This paper identifies essential structural domains of DivIVA in Actinomycetota by analyzing truncated variants and chimeric proteins, showing that polar growth depends on Actinomycetota-specific amino acid motifs.

The paper uses cryo-EM to determine the structure of bacteriophage 7-7-1 and shows it uses capsid fibers for initial host attachment.

This paper shows that CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex capable of synthesizing cellulose in vitro.

The paper identifies a new protein sensor class (CheWS) in Treponema denticola that links spirochete morphology, persistence, and chemotaxis through SAM sensing.

This paper presents a microfluidics platform for isolating and analyzing bacteriophages from environmental samples, improving efficiency over conventional methods.

This study determines the high-resolution structure of a jumbo bacteriophage infecting Klebsiella pneumoniae, revealing its complex tail fibers that enable infection of multiple capsular polysaccharide types.

This study shows mycobacteria can form viable cell wall-deficient cells undetectable by conventional diagnostics, likely contributing to persistent infections.

This study shows bacteria can shed their cell wall to resist phage infection, remaining viable under osmoprotective conditions and reverting to a walled state, which may limit phage therapy effectiveness.

This study shows that UVC irradiation at cryogenic temperatures can inactivate pathogens without damaging their structure, making them suitable for cryo-EM analysis.

The paper uses electron cryo-tomography to analyze membrane projections and associated protein complexes in bacterial species, identifying diverse structures and protein associations.

The paper shows Streptomyces spores use motile bacteria's flagella to transport themselves to plant roots, facilitated by surface proteins.

This study shows that FilP, a cytoskeletal protein, is required for S-cell formation in Kitasatospora viridifaciens under oxygen-limiting conditions.

This study identifies an alternative P2 symmetry in chemoreceptor arrays of Treponema denticola, adapted to high membrane curvature, revealing new structural features and functional roles of CheA and CheW-CheR-like proteins.

The paper investigates how engineered chemoreceptor complexes stabilize a kinase-off state by sequestering kinase and substrate domains, using multiple biophysical techniques.

This study uses cryo-electron tomography to show that teichoic acids anchor distinct cell wall lamellae in the apically growing bacterium Streptomyces coelicolor.

The paper traces the evolutionary origin of the F7 chemosensory system in E. coli by analyzing ancestral forms in related bacteria and identifying structural and functional changes.

This study investigates structural and proteomic changes in Vibrio cholerae during the viable but non-culturable state using electron cryo-tomography and proteomic analysis.

The paper shows γ-proteobacteria eject their polar flagella under nutrient depletion, leaving behind motor relic structures in the outer membrane.

This study shows filamentous actinomycetes can naturally form cell wall-deficient S-cells under hyperosmotic stress, which can transition to stable wall-less forms with prolonged exposure.

The paper presents an open-source cryo-storage system to improve sample storage efficiency and organization in cryo-EM laboratories.