Guixue Hou

This study integrates proteogenomic analyses of esophageal squamous cell carcinoma to identify molecular subtypes and potential therapeutic strategies.

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

This study uses multi-omics data to analyze immune and metabolic changes in mountain climbers during acclimatization and extreme altitude exposure.

This study identifies 30 novel metabolite-gene associations in 34,394 Chinese pregnant women and finds pleiotropy and causal relationships between metabolites and diseases.

IntroSpect improves HLA binding peptide identification sensitivity by 80% using motif-guided database building, while maintaining high accuracy and FDR control.

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.

EPIP predicts MHC-I epitope presentation by integrating mass spectrometry-derived motifs and tissue-specific RNA-seq data, outperforming existing methods in independent validation.

This study evaluates SWATH-MS across 11 labs, showing consistent detection and quantification of over 4,000 proteins with reproducible quantitative data.