Patrick Kwok Shing Ng

This study identifies satellite DNA fragility and ecDNA oncogene amplification in canine osteosarcomas using long-read sequencing, revealing genomic instability mechanisms relevant to human cancer.

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.