Andrew E. Goodspeed

This study shows that CDH1 loss in human mammary epithelial cells remodels gene expression and lineage identity toward a luminal progenitor-like state, contributing to ILC oncogenesis.

This study shows that IFNγ and IL-4 regulate lytic infection in myeloid cells via JAK/STAT signaling, with IFNγ restricting lytic replication through multiple mechanisms.

This study shows estradiol suppresses microglial immunity and promotes breast cancer brain metastasis, with E2 suppression enhancing anti-tumor responses and synergizing with radiotherapy.

This study shows that lung epithelial cells promote breast cancer metastasis through wound repair mechanisms, and targeting CREB signaling with PDE4 inhibitors can reduce metastatic outgrowth.

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

This study uses single-cell RNA-sequencing to analyze transcriptional heterogeneity in Ewing sarcoma and identifies TSPAN8 as a novel therapeutic target.

This study uses spatial transcriptomics to analyze Ewing sarcoma tumors, finding that localized tumors have more stromal enrichment and unique immune signals compared to metastatic tumors.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.