Jianting Sheng

CodeCytos improves spatial molecular imaging analysis by enabling dynamic, programmable interaction with tissue data, outperforming baseline approaches in custom feature exploration.

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

MUSTANG performs multi-sample spatial transcriptomics analysis by integrating cross-sample similarity and spatial correlation to improve cellular deconvolution.

The paper introduces LINEMAP, a computational framework that traces and maps mutation networks in single-cell lineage dynamics using homing CRISPR technology.