Bridgett Sharp

This study compares the replication ability of avian and mammalian-derived clade 2.3.4.4b H5N1 viruses in epithelial cells from different species, finding that mammalian strains replicate more broadly.

The paper shows that pre-existing immunity from H1N1 infection or vaccination can protect against lethal HPAI H5N1 clade 2.3.4.4b challenge in mice and ferrets, independent of hemagglutination inhibition titers.

This study investigates the effects of oral exposure to pasteurized HPAI H5N1 virus in milk on immune response and mortality in mice, finding limited health risk and no prevention of immune-mediated protection.

This study compares antibody profiles from maternal influenza vaccines in mice, showing LAIV and rHA provide better offspring protection than TIV.

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

The paper reports the detection of H5N1 AIV clade 2.3.4.4b in Chile in 2022, linked to migratory birds and showing phylogenetic similarity to Peruvian isolates.