Cell BiologybioRxivPreprint
Reduced insulin and IGF-1 signalling synergistically extend healthspan in male mice
Andrew MN Walker, Nicole T Watt, Nele Warmke…·Richard M Cubbon
This study shows that reducing both insulin and IGF-1 signaling in male mice synergistically extends healthspan, as evidenced by longer survival and preserved nesting behavior compared to single-gene knockouts.
DOI 10.1101/579110