Daheng He

This study identifies NHE1 as a regulator of T-ALL leukemia-propagating activity and mitochondrial fitness, showing its therapeutic potential.

The paper identifies PLK1-mediated phosphorylation of PHGDH as a mechanism driving serine metabolism reprogramming in advanced prostate cancer, increasing reliance on exogenous serine uptake.

This study identifies mTORC1's role in regulating the CCL24-CCR3 axis, showing its impact on granuloma formation and maintenance in sarcoidosis, with therapeutic implications.

This paper demonstrates a magnetically gated CRISPR platform that spatially confines genome editing to target tissues, enabling localized immunotherapy in a murine tumor model.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.