Kaiming Zhang

This study determines the structure of human NSUN2 in complex with tRNA substrates, revealing its mechanism of substrate recognition and catalytic specificity, and identifies a small-molecule inhibitor.

The paper presents cryo-EM structures of type I and II Lamassu systems from different bacteria, revealing their architecture and mechanism of DNA cleavage.

The paper describes a Kaggle competition for RNA 3D structure prediction, showing that template-based methods can outperform deep learning approaches.

This paper evaluates blind predictions of dynamic water and ion ensembles around RNA using cryo-EM densities from CASP16, finding that molecular dynamics approaches perform best.

Two Tetrahymena ribozyme cryo-EM maps (2.2 and 2.3 Å) reveal cross-validated ordered waters and Mg2+ ions, plus reproducible diffuse solvent density resembling molecular dynamics water networks.

This paper determines the 3D structures of SL5 RNA domains from six coronaviruses, revealing conserved tertiary features with implications for protein-binding and antiviral targets.