Author

Mark Donowitz

Johns Hopkins UniversityORCID 0000-0003-0477-8824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Ruxian Lin· 2 shared Varsha SinghiD· 2 shared Alaullah SheikhiD· 1 shared Albert Z. LiuiD· 1 shared Barbara A. SmithiD· 1 shared Bernhard B. SingeriD· 1 shared Bipul SetuiD· 1 shared Blake A. JohnsoniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPhysiology

Ruxian Lin

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4 papers

Recent·Most cited

PhysiologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewedSep 10, 2025

Differential Regulation of NHE3 Expression in Type 1 and Type 2 Diabetic Intestine: Impaired Endosomal Regulation of NHE3 Expression in Type 1 Diabetes

Varsha Singh, Ruxian Lin, Laxmi Sunuwar…·Rafiquel I. Sarker

This study identifies distinct mechanisms of NHE3 regulation in type 1 and type 2 diabetes, showing SNX17 loss in T1D reduces NHE3 stability while T2D involves transcriptional downregulation in the colon.

DOI 10.1152/ajpcell.00590.2025

mouseproteomics

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PhysiologyiSciencePeer-reviewedApr 17, 2025

Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide.

Rong Yan, Zixin Zhang, Hugo R. de Jonge…·Varsha Singh

The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.

3 citations

humanbulk RNA-seq

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MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedSep 12, 2024

Host-derived CEACAM-laden vesicles engage enterotoxigenic E. coli for elimination and toxin neutralization.

Alaullah Sheikh, Debayan Ganguli, Tim J. Vickers…·James M. Fleckenstein

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.

5 citations

humanproteomics

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Cell BiologyScience AdvancesPeer-reviewedApr 3, 2024

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Yi Wei Dong, Blake A. Johnson, Linhao Ruan…·Rong Li

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

26 citationstop 3%

humanorganoid / primary culture

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