Lei Xu

This study identifies SPHK2 as a therapeutic target in G3MB, showing that its inhibition restores anti-tumor immunity and improves survival in mouse models, with enhanced effects when combined with radiation.

This study shows that combining anti-PD1 treatment with radiation therapy for vestibular schwannomas improves tumor control, reduces radiation dose, and elicits systemic anti-tumor effects.

This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.

This study identifies IL-6 and EGFR signaling as therapeutic targets for schwannomatosis, showing combined blockade reduces both pain and tumor growth in preclinical models.