Gavin James Wright

This paper shows that a single dose of an unmodified anti-IFX monoclonal antibody can cure T. vivax infections in mice, with no detectable parasites in peripheral tissues.

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

This study reveals how ARID1A-mediated transcriptional rewiring drives resistance to MAPK inhibitors in melanoma by altering signalling pathways, immune interactions, and receptor dynamics, highlighting potential targets for combinatorial therapies.

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

The paper uses AlphaFold-Multimer to predict a pentameric complex involved in mammalian egg-sperm fusion, including TMEM81, a previously uncharacterized sperm protein.

This study identifies Cachd1 as a novel Wnt receptor-interacting protein essential for left-right neuronal asymmetry in zebrafish.

This study shows that Adgrd1 regulates oviductal fluid flow and embryo transport in mice, with its absence causing infertility due to impaired embryo release from the ampullary-isthmic junction.

CEN-tools identifies context-specific essential genes using CRISPR screen data, revealing gene dependencies across biological contexts and integrating with protein-protein interaction networks.

The paper profiles single-cell transcriptomes from the human first trimester fetal-maternal interface, revealing cellular composition and interactions critical for placentation.