Daniel Allen Nissley

The paper identifies how protein stability, turnover, and abundance influence the connectivity of protein-protein interaction networks in yeast.

ANYI integrates yeast PPI data with sixteen biophysical and regulatory annotations to enable cross-layer interactome analysis.

The paper examines age-related structural changes in yeast proteins using mass spectrometry and simulations, finding that entanglement misfolding contributes to proteome aging.

This paper presents a computational pipeline for designing therapeutic antibodies using AI and physics-based methods, showing improved binding and developability across SARS-CoV-2 variants.

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

This study compares protein structure prediction methods to experimental folding data, finding their simulated dynamics do not better capture folding pathways than simple classifiers.