John Macky Marshall

This study develops split suppression gene drives in Aedes aegypti, showing that inheritance efficiency and reproductive fitness costs must be balanced for effective population suppression.

The paper outlines a target product profile for a rapid diagnostic test to detect gene drive mosquitoes in the field, focusing on usability, sensitivity, and compatibility with pooled testing.

This paper evaluates Y-linked genome editors (YLEs) for rodent control, finding they are efficient for population elimination with modest release sizes and minimal spillover.

This paper develops behavioral state microsimulation models to study mosquito dispersal, showing that population structure arises from resource availability and behavioral states.

The paper uses genomic data and simulation modeling to show that Aedes aegypti populations in southern Australia can be eliminated with Wolbachia-infected male releases if rainwater tanks are removed first.

This paper extends close-kin mark-recapture methods to estimate mosquito dispersal parameters and barrier strength using simulations of Aedes aegypti populations.

MGDrivE 3 simulates mosquito genetic control tools and their epidemiological impacts using a decoupled vector-human framework, incorporating detailed malaria transmission models and surveillance modules.

MGSurvE optimizes trap placement for genetic surveillance of mosquito populations to minimize time to detect alleles of interest, considering ecological and biological factors.

The paper identifies divergent regions in homomorphic sex chromosomes using diploidized nanopore assembly from a single male, revealing a highly divergent region in Aedes aegypti with potential for genetic control.

This paper evaluates the cost-effectiveness of precision-guided sterile insect technique (pgSIT) for malaria control in The Gambia, finding it to be a cost-effective and economically beneficial approach.

The paper demonstrates a convertible gene-drive system that transitions from a split-drive to a full-drive element in the spo11 locus, showing similar final introgression levels despite initial slower kinetics.

MGDrivE 2 simulates gene drive systems with seasonal and epidemiological dynamics to predict their impact on disease transmission.

This study tests split gene-drive systems in Drosophila that target essential genes, showing variable copy efficiencies and sex-biased transmission, with outcomes that can be inherently confined.

This paper develops a CRISPR-based sterile insect technique to eliminate Aedes aegypti mosquitoes in controlled environments.

This paper develops a gene-drive rescue system in Anopheles stephensi to efficiently modify mosquito populations for malaria control.

The paper introduces a split-gene-drive system that enhances safety and flexibility in CRISPR-based gene drive applications through trans-complementation.

MGDrivE simulates gene drive spread in mosquito populations, showing how different architectures affect population replacement and suppression.

This study analyzes genome-wide divergence in invasive Aedes aegypti populations in California, identifying three genetic clusters and evidence of hybridization among them.

This paper describes a CRISPR-based method called precision guided SIT (pgSIT) that produces 100% sterile male insects, enhancing the scalability and effectiveness of insect population control.

The paper develops a synthetic Medea gene drive in D. suzukii, showing high inheritance bias but noting resistance and fitness costs that limit its spread.

The paper reviews CRISPR-based gene drive systems to assess their ability to spread in populations and be recalled if needed.

This study uses an agent-based model to compare three mosquito-control strategies in spatially heterogeneous settings, finding that spatial heterogeneity significantly affects disease transmission and intervention effectiveness.