Douglas T. Fearon

This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.

This study shows that crosslinked CXCR4 on T cells reduces their motility and increases adhesion through a non-Gi-dependent pathway involving PTK2B and integrin β4.

The paper identifies MED12-p63 interaction as a driver of basal identity in PDAC through genetic screens and biochemical analysis.