Author

Philip Moresco

Cold Spring Harbor LaboratoryORCID 0000-0003-4020-959XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Douglas T. FearoniD· 2 shared Adrian R. KraineriD· 1 shared Aktan AlpsoyiD· 1 shared Allison C. Schier· 1 shared Camila O. dos SantosiD· 1 shared Christopher R. VakociD· 1 shared Damianos S. SkopelitisiD· 1 shared David Arthur TuvesoniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Douglas T. FearonORCID

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2 papers

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 1, 2025

Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells

Philip Moresco, Jonathan P. Kastan, Jung‐In Yang…·Douglas T. Fearon

This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.

8 citations

humanproteomics

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Cancer BiologyNature GeneticsPeer-reviewedJun 17, 2024

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma

Diogo Maia-Silva, Patrick J. Cunniff, Allison C. Schier…·Christopher R. Vakoc

The paper identifies MED12-p63 interaction as a driver of basal identity in PDAC through genetic screens and biochemical analysis.

19 citations

humangenetic perturbation / CRISPR

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