Gira Bhabha

The paper uses scRNA-seq to study host and parasite transcriptional responses to Encephalitozoon intestinalis infection in Caco-2 and Vero cells, finding limited host response and a parasite developmental program.

The paper reports cryo-EM structures of P. aeruginosa PA3214 and E. coli PqiC lipoproteins interacting with their MCE protein partners, revealing their assembly and functional interactions.

This study investigates the polar tube firing dynamics and ultrastructure of EHP, identifying optimal activation conditions and revealing structural features important for infection.

The paper introduces a modular bond-centric design approach for protein assemblies, demonstrating the successful creation of multiple polyhedral cages, 2D arrays, and 3D lattices with high success rates.

This study uses scRNA-seq to analyze transcriptional changes in human macrophages and Encephalitozoon intestinalis parasites during infection, revealing parasite developmental dynamics and host response.

The paper determines the structure of E. coli LetAB, identifies LetA as a novel transporter family, and proposes a mechanism for lipid transport using proton-motive force.

The paper uses cryo-electron tomography to reveal the in situ architecture of the polar tube invasion apparatus in microsporidian parasites.

This study identifies YhdP as a phospholipid transporter spanning the bacterial cell envelope, using AlphaFold, electron microscopy, and simulations to show its structure and function.

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.

The paper describes protocols for preparing and imaging mammalian cell monolayers using SBF-SEM, including embedding methods and data collection optimization.

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

This paper identifies two conformations of the γ-tubulin ring complex (γ-TuRC) using cryo-EM and proposes a model for how conformational changes facilitate microtubule nucleation.

The paper shows the D614G mutation in SARS-CoV-2 Spike protein increases infection efficiency in multiple human cell lines by enhancing proteolytic resistance.

The paper introduces a two-color localization method to measure nanometer-scale distances between fluorophores with high accuracy, revealing a 4 nm conformational change in dynein.