Sarah A. Tersey

This study shows dietary glutamate influences ImP production via microbial competition, affecting glucose tolerance and systemic ImP levels.

This study identifies sex-specific islet responses to inflammation and shows that estrogen reduces inflammatory signaling and promotes immune tolerance in beta cells, contributing to sex differences in type 1 diabetes susceptibility.

This study identifies GPR31 as a key inflammatory regulator in pancreatic islets, showing its role in β-cell stress and macrophage activation in type 1 diabetes.

This study shows that inhibiting the integrated stress response (ISR) reduces macrophage inflammation and migration in a mouse model of type 1 diabetes.

This study investigates the distinct roles of hypusinated and unhypusinated eIF5A isoforms in pancreas development and function using zebrafish and mouse models.

This study shows that inhibiting 12-LOX improves glucose homeostasis and reduces obesity-related inflammation in human gene replacement mice.

This study shows that inhibiting 12-LOX with VLX-1005 delays autoimmune diabetes onset in human gene replacement mice by altering inflammatory pathways and immune cell infiltration.

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.