Pavel Barahtjan

This study quantifies lipid sorting during clathrin-mediated endocytosis and finds that lipid asymmetry in the plasma membrane explains observed partitioning, with minimal selectivity for cytoplasmic leaflet lipids compared to non-vesicular trafficking.

The paper maps the lipidomic architecture of the adult mouse brain at micrometric scale, revealing spatial lipid organization and its functional relevance.

The paper introduces bifunctional monosaccharide probes to study their intracellular localization, finding they preferentially accumulate in RNA-rich nuclear compartments.

The paper quantifies lipid transport between organelles in mammalian cells, revealing non-vesicular transport as a key mechanism for species-specific lipid sorting.

The paper introduces GEQO biosensors for absolute analyte quantification in single cells without requiring specialized equipment, showing they account for buffering and retain time trace information.

This study shows that disrupting plasma membrane lipid asymmetry in mammalian cells alters cellular energetics by shifting metabolism from anabolic to catabolic states.