André Nadler

This study quantifies lipid sorting during clathrin-mediated endocytosis and finds that lipid asymmetry in the plasma membrane explains observed partitioning, with minimal selectivity for cytoplasmic leaflet lipids compared to non-vesicular trafficking.

The paper identifies lipid specificity in membrane organizing protein complexes by mapping lipid-protein interactions and demonstrating phosphatidylethanolamine's role in stabilizing NDC1 and MIC60.

The paper introduces bifunctional monosaccharide probes to study their intracellular localization, finding they preferentially accumulate in RNA-rich nuclear compartments.

The paper evaluates the crosslinking efficiency of bifunctional diazirine lipid probes using STARD10 and mass spectrometry, finding that only 5% form covalent protein-lipid crosslinks.

The paper introduces bifunctional ether lipid probes to study intracellular transport kinetics and identifies differences in transport rates between alkyl- and vinyl-linked ether lipids.

The paper identifies a redox-sensitive cysteine in p21 that regulates its interaction with CDKs, controlling cell cycle progression and proliferation through a feedback loop.

The paper quantifies lipid transport between organelles in mammalian cells, revealing non-vesicular transport as a key mechanism for species-specific lipid sorting.

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

The paper introduces GEQO biosensors for absolute analyte quantification in single cells without requiring specialized equipment, showing they account for buffering and retain time trace information.

This study shows that disrupting plasma membrane lipid asymmetry in mammalian cells alters cellular energetics by shifting metabolism from anabolic to catabolic states.

This paper introduces a correlative light and electron microscopy workflow to quantify lipid densities in membrane nanodomains and finds sphingomyelin partitions into specific endosomal structures.

The paper shows Hedgehog signaling enhances glycolytic ATP production in Drosophila wing disc tissue, revealing a feedback loop between signaling and energy metabolism.