Pierre A. Coulombe

This study identifies a phosphorylation-dependent conformational change in the K19 head domain that affects filament assembly and interactions with GSK3β, but not 14-3-3 proteins.

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

The paper shows that K15 promotes a progenitor cell state in skin epidermis by counteracting K14's suppression of YAP1, a Hippo signaling effector.

This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.

This study shows that TGFβ1-TNFα-induced neutrophil chemokine secretion in breast tumor cells occurs independently of EMT.

This study shows neutrophils release nuclear DNA via exosomes to resolve sterile inflammation, with implications for treating inflammatory diseases.

The paper identifies a keratin 17- and PKCα-dependent mechanism that transiently amplifies neutrophil influx in stressed skin, revealing a novel pathway in chronic inflammatory skin diseases.

The paper reanalyzes single-cell RNA-seq data to confirm and extend understanding of keratin gene expression patterns in epithelial tissues.

This study identifies that Keratin 19 sequesters HNRNPK in the cytoplasm, stabilizing mRNAs involved in cancer progression.