Yang Xu

This study designs high-fidelity CRISPR-Cas variants using a physics-driven approach combining molecular dynamics and protein language models, achieving significant improvements in fidelity with minimal experimental validation.

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

This study shows neutrophils release nuclear DNA via exosomes to resolve sterile inflammation, with implications for treating inflammatory diseases.

The paper identifies a keratin 17- and PKCα-dependent mechanism that transiently amplifies neutrophil influx in stressed skin, revealing a novel pathway in chronic inflammatory skin diseases.