Joshua J. Cull

EGFR-family ligand mRNAs shift in failing human hearts; NRG1 and EGF drive distinct, differently ERBB2-dependent transcriptional programmes in rat cardiomyocytes; afatinib blunts mouse angiotensin II hypertrophy but worsens fibrosis.

This paper evaluates speckle-tracking echocardiography in mice to assess cardiac function and drug effects, finding it more sensitive than traditional methods in detecting regional changes.

This paper shows that striatin (STRN) in cardiomyocytes is necessary for angiotensin II-induced cardiac hypertrophy and remodelling in mice, but not STRN3.

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.