Rachel Fearns

The paper identifies an age-associated immune-poised state in human bronchial epithelial cells that mediates RSV resistance in adults by enhancing RIG-I-STAT3 signaling.

The paper shows eIF4E3 enables efficient translation of viral mRNAs with short 5' UTRs, unlike the canonical eIF4E1, and identifies this as a mechanism used by viruses like VSV to bypass host translation suppression.

This study shows RSV infection desensitizes β2AR in infant ASMCs via CXCL11-CXCR7 signaling, leading to airway resistance and potential therapeutic targeting.

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

This study determines the cryo-EM structure of the hPIV3 L-P polymerase complex, revealing structural features and interactions that may explain its dimerization and function in transcription and replication.