Jonathan Abraham

This study uses deep mutational scanning to analyze how amino-acid mutations affect the pH stability and cell entry function of the Junin virus glycoprotein complex.

This study determines cryo-EM structures of orthoflaviviruses bound to LDLR family receptors, revealing distinct binding modes and receptor engagement mechanisms.

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

This study determines the structure of HSV-1 helicase-primase inhibited by HPIs and reveals how it interacts with the replication fork complex.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.