Jason H. Yang

This study shows that bioenergetic stress from antibiotic treatment enhances antimicrobial resistance and persistence in E. coli through increased ROS, repair mechanisms, and stringent response activation.

The paper predicts Mtb fitness using a transcription factor activity-based machine learning model trained on RNA-seq data and regulatory network analysis.

This study identifies KatG catalase deficiency in INH-resistant M. tuberculosis as a factor contributing to hyper-susceptibility to bedaquiline.

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

This study identifies YlaN as an Fe(II) binding protein in S. aureus that relieves Fur-mediated repression of gene expression during Fe deprivation.