Jonathan G. Heddle

This paper designs de novo integrated domains using AI tools to enable plant NLR receptors to recognize non-cognate pathogen effectors, demonstrating functional immune responses and structural fidelity.

The paper demonstrates a method to create extended plasmonic nanostructures using tobacco mosaic virus coat protein templates, forming hexagonal or square packed sheets and core-shell nanorods with gold nanoparticles.

This study demonstrates how a circularly permuted enzyme can assemble into various hollow structures using pentamers, guided by structural and geometrical principles.

This study reports high-resolution cryo-EM structures of tobacco mosaic virus coat protein disks, revealing new insights into viral assembly and differences between bacterial and plant-produced coat proteins.

This paper describes an artificial protein cage system that efficiently packages active enzymes while maintaining their catalytic activity through a post-assembly loading approach.

The paper presents cryoEM structures of Escherichia coli DNA gyrase with DNA loops, supporting a ratchet-and-pawl mechanism for ATP-powered supercoiling.