Scott O. Zeitlin

This study shows that reducing huntingtin in liver cells leads to metabolic changes, altered cell adhesion, and disrupted liver zonation patterns in mice.

This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.

This study shows that reducing huntingtin protein levels decreases somatic instability in CAG-expanded loci in both mouse models and human neurons.