Nobuko Akiyama

This study investigates the second impact of acute total body irradiation on thymic epithelial cells, finding reduced mTEC frequencies and altered gene expression during the second impact phase.

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

The paper quantifies how irradiation affects iNKT cell development in the thymus of mice by analyzing TCR repertoire changes and recovery dynamics.

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

This study shows that RANKL and CD40L signaling maintain mTEC frequency and TEC progenitor properties in the adult thymus through direct and indirect mechanisms.

This study develops a cryopreservation method for blood cells under ISS constraints, demonstrating viability recovery and subset analysis using flow cytometry.

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

The paper constructs a single-cell atlas of transcribed cis-regulatory elements in the human genome, revealing gene regulation patterns and trait-gene relationships across cell populations.