John J. G. Tesmer

This study identifies structural changes in P-Rex1 upon activation by PIP3 and inhibition by IP4, revealing how these interactions regulate its GEF activity.

This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.