Lan Zhao

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

The paper identifies BX-912 as a compound that rescues SOX17 gene targets and prevents pulmonary hypertension in mice.

This study shows that impaired SOX17 expression increases pulmonary arterial hypertension risk by failing to suppress RUNX1, leading to endothelial dysfunction, and that RUNX1 inhibition can mitigate this condition.

This study shows that an AKAP13 genetic variant promotes fibrosis by altering epithelial signaling, and inhibiting AKAP13's RhoGEF activity reduces fibrotic markers in IPF models.

This study identifies ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension and shows that the antibiotic CTC inhibits this pathway.