Aaron Palmer Esser-Kahn

This study shows that β-glucan-induced trained immunity in mice enhances antibody levels after vaccination by improving antigen presentation and T-cell responses.

This study shows that intranasal immunization with CPAF and cyclic-di-AMP reduces bacterial burden in mice infected with Chlamydia muridarum by inducing memory CD4 T cell responses.

The paper identifies a small molecule, A1155463, that induces trained immunity in macrophages without being immunogenic, enhancing anti-tumor resistance in mice.

This study uses machine learning to guide high-throughput screening and discovers small molecules that modulate innate immune pathways, with some showing up to 15-fold suppression of NF-κB activity.