BiochemistryScience SignalingPeer-reviewed
Specificity and promiscuity of JAK recruitment regulates pleiotropy of cytokine-receptor signaling
Eyal Zoler, Thomas Meyer, Junel Sotolongo Bellón…·Gideon Schreiber
The paper investigates JAK recruitment specificity and promiscuity in cytokine-receptor signaling, finding that JAKs can interchangeably bind to receptors, leading to cell type-specific signaling pleiotropy.