Gideon Schreiber

This study uses in vitro evolution to show that stringent selection pressures rapidly converge on Omicron-like mutations in SARS-CoV-2 spike protein, mirroring real-world viral evolution patterns.

This study shows IRF1 regulates antiviral immunity through both cytokine signaling and direct promoter binding, affecting gene expression in a context-dependent manner.

This paper shows that STAT5A deficiency disrupts actin networks, leading to mitochondrial dysfunction and IFN-beta production, which can be reversed by restoring ACTN1.

The paper investigates JAK recruitment specificity and promiscuity in cytokine-receptor signaling, finding that JAKs can interchangeably bind to receptors, leading to cell type-specific signaling pleiotropy.

RBD-62, a high-affinity ACE2 antagonist, limits SARS-CoV-2 replication in both upper and lower airways in rhesus macaques without blocking memory responses or causing anti-drug immunity.