Nicanor González‐Morales

This study shows adult Drosophila muscles can fully remodel damaged myofibrils, with filamin mechanosignaling playing a critical role in repair, and identifies a progressive deterioration during aging.

This study uses AlphaFold2 to screen proteins that bind to the open conformation of Drosophila filamin Cheerio, identifying 132 hits that specifically recognize the open state.

The paper investigates how filamin protects myofibrils from contractile damage by altering its mechanosensory region in Drosophila indirect flight muscles.