Seung Young Lee

NicheProt enables cell-type and microregion-resolved proteomic analysis by isolating specific cells from defined tissue compartments using 3D microscopy and photobleaching-mediated barcoding.

This paper develops a CD40 agonistic-monovalent streptavidin fusion antibody that delivers neoantigen peptides to APCs, enhancing cancer vaccine efficacy and tumor regression in mice.

This study identifies early vascular leakage beyond the injury epicenter as a driver of secondary pathology after SCI and shows that stabilizing the blood-spinal cord barrier improves recovery.

This study develops a wireless optogenetic system to control genome editing and tumorigenesis in mice by using light-regulated recombinase and implantable devices.

This paper develops a method to obtain correlative multiscale 3D images of mouse tumors using sequential light sheet and confocal fluorescence microscopy, enabling spatial analysis of immune responses and metastasis.

This study shows that timing anti-PD-L1 therapy after radiation enhances tumor response by preventing CTL depletion and improving PD-L1 blockade.

This paper introduces an LED photobleaching method to enhance 3D immunofluorescence microscopy multiplexity for tumor microenvironment analysis, achieving 8-plex imaging.